The first task of sending emails from SAP is quite simple. Here is a simple step-by-step guide: 1. make sure that the SMTP scenario is running on your SAP NetWeaver system. For this you need the SAPconnect and the SMTP configuration. 2. make sure that SAPconnect is configured for mail sending. 3. use a method like 'SO_NEW_DOCUMENT_ATT_SEND_API1' or 'CL_BCS' class in your ABAP program to actually create and send the email.
For a detailed explanation of how to configure SAP to send e-mails, see the SAP documentation or the SAP Help Center. However, processing the response from the receiving mail server is more complex, as these responses are usually sent by e-mail and end up on the mail server and not in the SAP system. You need some form of automation to read these emails and process them in SAP. One of the approaches could be to configure an IMAP or POP3 mail client (depending on which protocol your mail server supports) on SAP and write an ABAP program that regularly queries and processes the email account that receives the feedback from the mail server. There are also a number of partner solutions that can help you achieve this, please note that this is a non-trivial task both in terms of configuration and coding as well as security as you will probably need to protect both the email account and the mail server to prevent misuse.
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